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Small Round White Pill With Letters M T7 – Methadone is a narcotic pain reliever most commonly used in the treatment of opioid addiction and addiction. Under medical supervision, methadone can allow someone addicted to opioids to detox and withdraw with minimal or reduced symptoms.
Methadone typically comes in pill form with varying dosage strengths. There are numerous companies that manufacture and distribute methadone under different brand names, and each lab creates the pills differently.
Small Round White Pill With Letters M T7
Methadone pills often look different depending on dosage and manufacturer. Each pharmaceutical company has a different brand name for the drug, and many generics are also available. Some common iterations include:
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Methadone may also be formulated as a liquid and the generic version may have different physical properties not listed above.
Methadone has a high potential for abuse and can lead to dependence and addiction. Seeking prompt professional help for methadone abuse is essential to avoid serious health risks, including addiction.
If you or someone you know is struggling with a methadone or other opioid addiction and needs help, please call our toll-free helpline 760-548-4032. Our admissions coordinators are available 24 hours a day to help you find a treatment program that will work for you. Get help now – call us today. Prolonged use of tramadol hydrochloride tablets during pregnancy may result in abstinence in the newborn. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, can be life-threatening if not recognized and treated, and requires treatment according to protocols developed by neonatology specialists. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Advise pregnant women on long-term opioid use of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment is available.
Prolonged use of tramadol hydrochloride tablets during pregnancy may cause withdrawal in the newborn. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, can be life-threatening if not recognized and treated, and requires treatment according to protocols developed by neonatology specialists. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Advise pregnant women on long-term opioid use of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment is available [see Precautions]. Use in Specific Populations (8.1) and Patient Counseling Information (17)].
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Long-term use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome. Available data on tramadol hydrochloride tablets in pregnant women are insufficient to report a drug-related risk for major birth defects and miscarriage.
Long-term use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome. Available data on tramadol hydrochloride tablets in pregnant women are insufficient to report a drug-related risk for major birth defects and miscarriage. In animal reproduction studies, administration of tramadol during organogenesis reduced fetal weights and reduced ossification in mice, rats, and rabbits at 1.4, 0.6, and 3.6 times the maximum recommended human daily dose (MRHD). Tramadol reduced pup body weight and increased pup mortality at 1.2 and 1.9 times the MRHD [see Table of Materials]. Data]. Based on animal data, advise pregnant women of the potential risk to the foetus. The estimated background risk of major birth defects and miscarriages for the indicated population is unknown. Against the background of all pregnancies there is a risk of birth defects, loss or other negative consequences. In the US general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.
Long-term use of opioid analgesics for medical or non-medical purposes during pregnancy may cause respiratory depression and physical dependence in neonatal and neonatal opioid withdrawal syndrome shortly after birth.
Long-term use of opioid analgesics for medical or non-medical purposes during pregnancy may cause respiratory depression and physical dependence in neonatal and neonatal opioid withdrawal syndrome shortly after birth. Neonatal opioid withdrawal syndrome may manifest as irritability, hyperactivity, and abnormal sleep patterns, high-pitched crying, tremors, vomiting, diarrhea, and inability to gain weight. The onset, duration, and severity of neonatal opioid withdrawal syndrome vary with the specific opioid used, duration of use, timing and amount of maternal last use, and rate of elimination of the drug by the newborn. Observe neonates for signs and symptoms of neonatal opioid withdrawal syndrome and manage accordingly. Warnings and Precautions (5.5)]. Neonatal seizures, neonatal abstinence syndrome, fetal death and stillbirth have been reported post-marketing.
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Tramadol has been shown to be embryotoxic and fetotoxic in rats (120 mg/kg), rats (25 mg/kg), and rabbits (75 mg/kg) at maternally toxic doses, but was not teratogenic at these dose levels. On a mg/m2 basis, these doses are 1.4, 0.6 and 3.6 times the maximum recommended human daily dose (MRHD) for mouse, rat and rabbit, respectively. No drug-induced teratogenic effects were observed in strains of mice (up to 140 mg/kg), rats (up to 80 mg/kg), or rabbits (up to 300 mg/kg) treated with tramadol by various routes. Embryo and fetal toxicity consisted mainly of decreased fetal weights, decreased skeletal ossification, and increased excess ribs at maternally toxic dose levels. Transient delays in developmental or behavioral parameters were also seen in offspring from dams of rats allowed to breed. Embryo and fetal death was reported in only one rabbit study at 300 mg/kg, a dose that would cause excessive maternal toxicity in the rabbit. The dosages administered for mouse, rat and rabbit are 1.7, 1.9 and 14.6 times the MRHD, respectively. Tramadol has been evaluated in pre- and postnatal studies in rats. Mothers receiving oral (gavage) dose levels of 50 mg/kg (1.2 times the MRHD) or higher had reduced progeny weight and decreased early lactation pup survival at 80 mg/kg (1.9 times the MRHD).
Tramadol hydrochloride tablets are not recommended for prenatal medication or postpartum analgesia in nursing mothers as their safety in infants and neonates has not been studied.
Tramadol hydrochloride tablets are not recommended for prenatal medication or postpartum analgesia in nursing mothers as their safety in infants and neonates has not been studied. Tramadol and its metabolite O-desmethyltramadol (M1) are found in human milk. There is no information about the effects of the drug on the breastfed infant or the effects of the drug on milk production. The M1 metabolite is more potent than tramadol in binding to the mu opioid receptor [see Clinical Pharmacology (12)]. Published studies have reported tramadol and M1 in colostrum with administration of tramadol to nursing mothers in the early postpartum period. Women who are ultra-rapid metabolizers of tramadol may have higher-than-expected serum M1 levels, potentially leading to higher M1 levels in breast milk, which can be dangerous in their breastfed infants. The amount of tramadol secreted into breast milk in women with normal tramadol metabolism is low and dose-dependent. Inform patients that breast-feeding is not recommended during treatment with tramadol hydrochloride tablets because of the potential for serious adverse reactions, including excessive sedation and respiratory depression in a breastfed infant (see Warnings and Precautions (5.4)].
Warning: Addiction, Abuse and Abuse; Risk Assessment and Mitigation Strategy (REMs); Life-threatening Respiratory Depression; Accidental Ingestion; Ultra Rapid Metabolism of Tramadol and Other Risk Factors for Life-threatening Respiratory Depression in Children; Neonatal Opioid Withdrawal Syndrome; Interactions with Drugs Affecting Cytochrome P450 Isoenzymes; And Risks from Concomitant Use with Benzodiazepines or Other Cns Depressants
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Tramadol hydrochloride tablets expose patients and other users to the risks of opioid addiction, abuse and misuse, which can lead to overdose and death. Assess each patient’s risk before prescribing tramadol hydrochloride tablets and regularly monitor all patients for the development of these behaviors and conditions (see Warnings and Precautions (5.1)]
To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has requested a REMS for these products (see Warnings and Precautions (5.2)]
In accordance with REMS requirements, pharmaceutical companies with approved opioid analgesic products must offer REMS-compliant training programs to healthcare providers. Healthcare providers are strongly encouraged
Counseling patients and/or their caregivers on the safe use, serious risks, storage and disposal of these products with each prescription,
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Emphasize to patients and their caregivers the importance of reading the Medication Guide each time it is prescribed by their pharmacist, and
Serious, life-threatening or fatal respiratory depression can occur with the use of tramadol hydrochloride tablets. Monitor for respiratory depression especially during initiation of tramadol hydrochloride tablets or after a dose increase (see Warnings and Precautions (5.3)]
Life-threatening respiratory depression and death have occurred in children receiving tramadol. Some of the reported cases have occurred following tonsillectomy and/or adenoidectomy, in at least one case there was evidence that the child was an ultrarapid metabolizer of tramadol due to a CYP2D6 polymorphism (see Warnings and Precautions (5.4)]
. Tramadol hydrochloride tablets are contraindicated in children younger than 12 years of age and in children younger than 18 years following tonsillectomy and/or adenoidectomy [see Precautions]. Contraindications (4)]
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.Avoid the use of tramadol hydrochloride tablets in adolescents aged 12-18 years with other risk factors that may increase their susceptibility to the respiratory depressant effects of tramadol [see Precautions].